International Journal of Environmental Chemistry and Chromatography
 
Year Of Started:      2015 Published By:   SBT JOURNALS
Frequency:   Yearly ISSN:                APPLIED

ANALYTICAL METHOD DEVELOPMENT OF TOLPERISONE HYDROCHLORIDE IN TABLET DOSAGE FORM BY UV VISIBLE SPECTROPHOTOMETRY

Mahaparale S. P.*, Ubale G., Roy M. A.

Three simple, precise and economical UV spec-trophotometric methods have been developed for estimation of Tolperisone Hydrochloride in bulk and pharmaceutical formulations. Tolperisone hydrochloride is a piperidine derivative and used as centrally-acting muscle relaxant. Tolperisone Hydrochloride has absorbance maxima at 260.0 nm in zero order spectrum method (Method A), in the first order derivative spectra, showed sharp peak at 247 nm when n = 1 (Method B). Method C is based on calculation of area under curve (AUC) for analysis of Tolperisone Hydrochloride in the wavelength range of 250 nm - 271 nm. The drug followed the Beer-Lambertís law in the concentration range of 5-40 μg/ml in all three methods. The results of the analysis, validated statistically and by recovery studies were found to be satisfactory.

 
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